We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
Read More
8
Vitamin B12 benefits in CFS patients
Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
B12 shows variable efficacy for ME
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
Most Useful Reviews
7.5
Chronic fatigue relief
5 people found this helpful
As I suffer from chronic fatigue syndrome, I started taking Vitamin B12, having read that it helps with nerve issues. The taste of this tablet is enjoyable, similar to a sweet. The price is very reasonable. I have been taking it for three years and will continue doing so.
Read More
9
Rapid symptom relief
1 people found this helpful
The strawberry flavour is delightful! I recommend it for children with Vitamin B12 deficiency. Following its use, my chronic fatigue syndrome symptoms disappeared within ten days. I felt revitalised, with no tiredness or mental confusion. It's like consuming a sweet!
Read More
9
Improved energy levels
1 people found this helpful
After a few weeks of using this product, my chronic fatigue syndrome has improved significantly. The strawberry flavour is appealing, and the quick-dissolving tablets make it convenient. I’ve noticed increased energy levels and better mental clarity.
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
B12 shows variable efficacy for ME
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
8
Potential effects on chronic fatigue
Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems.
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Read More
7
Vitamin B12's role in fatigue
Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.
We observed that a group of twelve outpatients, all women diagnosed with both fibromyalgia and chronic fatigue syndrome, participated in a study focused on understanding the role of vitamin B12 in their condition. While most of their blood lab results were normal, one significant finding stood out: all patients had elevated levels of homocysteine in their cerebrospinal fluid.
The study found a noteworthy link between these increased homocysteine levels and the degree of fatigue experienced by the patients. Moreover, low levels of vitamin B12 in the cerebrospinal fluid were correlated with feelings of fatigue, suggesting that vitamin B12 might play a vital role in how these patients feel day-to-day.
The researchers concluded that the elevation of homocysteine in the central nervous system could be indicative of fibromyalgia and chronic fatigue syndrome. They suggested that a deficiency in vitamin B12 might hinder the body's ability to regulate homocysteine, contributing to the symptoms of fatigue these patients experience. However, while vitamin B12 is shown to be important in this context, the study does not specifically isolate its effects from other contributing factors or treatments.
As I suffer from chronic fatigue syndrome, I started taking Vitamin B12, having read that it helps with nerve issues. The taste of this tablet is enjoyable, similar to a sweet. The price is very reasonable. I have been taking it for three years and will continue doing so.
Read More
9
Rapid symptom relief
1 people found this helpful
The strawberry flavour is delightful! I recommend it for children with Vitamin B12 deficiency. Following its use, my chronic fatigue syndrome symptoms disappeared within ten days. I felt revitalised, with no tiredness or mental confusion. It's like consuming a sweet!
Read More
9
Improved energy levels
1 people found this helpful
After a few weeks of using this product, my chronic fatigue syndrome has improved significantly. The strawberry flavour is appealing, and the quick-dissolving tablets make it convenient. I’ve noticed increased energy levels and better mental clarity.
Read More
9
Boosts immunity
Boost! It revives fatigue and boosts my immune system. The great taste dissolves quickly under my tongue.
Read More
9
Increases energy
Vitamin B12 has been invaluable in tackling my chronic fatigue syndrome. After a few weeks, I felt more energetic and clear-minded.
Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex and debilitating condition characterized by profound fatigue that doesn’t improve with rest and worsens with physical or mental activity. This crippling fatigue is often accompanied by a variety of symptoms, including sleep disturbances, cognitive difficulties, muscle pain, and joint pain. Unlike typical tiredness, the fatigue experienced in CFS is long-lasting, and it can significantly hinder everyday activities and overall quality of life.
The precise cause of CFS remains unknown, but it is believed to be influenced by a combination of genetic, environmental, immunological, and psychological factors. Diagnosis primarily relies on a careful assessment of symptoms, as there are no definitive laboratory tests available. Treatment options focus on symptom management and may include lifestyle changes, physical therapy, medication for pain management, and cognitive behavioral therapy. Given the complexity and variability of the condition, individuals with CFS should consult healthcare professionals who specialize in this area to develop personalized management strategies.
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in several vital functions in the human body. It is essential for red blood cell formation, neurological function, and DNA synthesis. Naturally occurring in animal products, the vitamin can be found in high concentrations in meat, fish, eggs, and dairy, making it particularly important for those following a vegetarian or vegan diet, as plant-based sources of B12 are limited and often require supplementation.
A deficiency in vitamin B12 can lead to serious health issues, including anemia, fatigue, memory problems, and nerve damage. Due to its significance, it's crucial for individuals, particularly those at risk of deficiency, to ensure adequate intake through diet or supplementation. For most adults, the recommended daily allowance (RDA) is around 2.4 micrograms, though pregnant or breastfeeding women may require higher amounts. If you're considering B12 supplements, it's advisable to consult with a healthcare provider to determine the best option for your specific needs and health status.
While there is no definitive cure for Chronic Fatigue Syndrome (CFS), some studies suggest that Vitamin B12 may play a supportive role in managing symptoms for certain individuals. B12 is essential for the production of red blood cells and the proper functioning of the nervous system, and deficiencies can lead to fatigue, weakness, and other health issues. For individuals with a B12 deficiency, supplementation may alleviate some fatigue-related symptoms. However, it’s important to note that not all CFS patients have low B12 levels, and supplementation should only be considered after consulting with a healthcare professional.
It's important to approach B12 supplementation thoughtfully. High doses can sometimes be unnecessary or even lead to side effects, and the effectiveness of B12 in alleviating fatigue can vary from person to person. For those suffering from CFS, a comprehensive treatment plan tailored to the individual's needs, including dietary adjustments, lifestyle changes, and possibly psychological support, may prove more beneficial overall. As always, speaking with a healthcare provider who is knowledgeable about CFS is key to determining the best approach for managing this complex condition.
Based on user reviews, the timeline for experiencing results from Vitamin B12 supplementation in relation to chronic fatigue syndrome varies. Some users report notable improvements as quickly as ten days after starting the supplement, indicating a revitalized feeling without tiredness or mental confusion Read Review. Others mention significant enhancements in their energy levels and mental clarity after a few weeks of consistent use Read Review.
Additionally, many reviews highlight a gradual accumulation of benefits over time, with sustained use leading to clearer mental states and better energy management Read Review. It's important to note that while some experience immediate relief, others may require a longer period before noticing significant changes in their symptoms.
The scientific research surrounding the use of vitamin B12 as a treatment for Chronic Fatigue Syndrome (CFS) presents mixed results. On one hand, studies such as the one involving vitamin B12 nasal drops indicate that approximately two-thirds of participants experienced improvements in fatigue levels and physical activity after treatment over three months [1]. This suggests a potential benefit for some individuals with CFS, presenting vitamin B12 nasal drops as a feasible alternative to injections. However, the effectiveness appears to vary significantly among patients, as some responders showed substantial improvement while others did not experience notable changes [2].
On the other hand, several studies highlight the need for caution. Research indicated that concurrent treatments among participants complicated the assessment of vitamin B12's efficacy, leading to an inconclusive understanding of its true impact [4]. In some cases, high-dose B12 injections did not yield significant relief for patients, emphasizing the importance of personalized treatment strategies [6]. Overall, while certain individuals might find relief through vitamin B12 supplementation, the scientific community suggests that more focused research is necessary to ascertain the vitamin's role and optimal use in managing CFS symptoms.
Users have shared a variety of positive experiences with Vitamin B12 in addressing symptoms related to chronic fatigue syndrome, suggesting that it may provide significant relief. For instance, one user noted that their symptoms entirely disappeared within ten days of starting the supplement, leading to a remarkable sense of revitalization with no fatigue or mental fog Read Review. Another contributor remarked on improved energy levels and mental clarity after a few weeks of use, highlighting the product's convenient quick-dissolving nature and enjoyable taste Read Review.
Moreover, many reviewers reported cumulative benefits over time, indicating a progressive enhancement in their overall well-being with sustained use. For instance, several users mentioned better muscle recovery, sustained energy throughout the day, and reduced irritability Read ReviewRead Review. Another noted that their mental state had improved significantly since beginning supplementation Read Review. While these experiences are promising, individual results may vary, and it's important for prospective users to monitor their own responses to the supplement.
Users report positive experiences when combining Vitamin B12 with other supplements to manage chronic fatigue syndrome. Many individuals highlight that Vitamin B12 enhances their energy levels and mental clarity, which becomes even more pronounced when taken alongside other supportive supplements. For example, one user noted improved muscle recovery and sustained energy throughout the day with regular use of Vitamin B12, particularly when paired with an overall health regimen aimed at combating fatigue Read Review.
A few reviewers specifically mentioned that Vitamin B12's effectiveness is amplified when used in conjunction with other nutrients tailored for energy production or overall wellness. For instance, another user expressed that regular administration of Vitamin B12 helped manage associated irritability and fatigue, especially when complemented by a balanced diet and other vitamins Read Review. These individual accounts suggest that while Vitamin B12 alone can provide relief for symptoms related to chronic fatigue syndrome, it may also be more effective as part of a comprehensive supplement strategy.
Users report a varied experience regarding the effective dosage of B12 for treating Chronic Fatigue Syndrome. Several individuals found significant improvements in their fatigue and energy levels with regular use of B12 supplements, particularly when taken consistently. For instance, one user mentioned that after just a few weeks of usage, they observed a notable enhancement in their symptoms, highlighting increased energy and mental clarity Read Review. Another user reported that a single tablet daily provided them with better overall wellbeing throughout the day Read Review.
However, a few reviews noted caution regarding higher doses. One user mentioned a megadose of four tablets daily led to a slight reduction in fatigue, implying that higher amounts should be approached carefully Read Review. This suggests that while B12 can be integral in managing Chronic Fatigue Syndrome, determining the right dose might require personal experimentation and monitoring of individual responses.
9
Rapid symptom relief
1 people found this helpful
The strawberry flavour is delightful! I recommend it for children with Vitamin B12 deficiency. Following its use, my chronic fatigue syndrome symptoms disappeared within ten days. I felt revitalised, with no tiredness or mental confusion. It's like consuming a sweet!
9
Improved energy levels
1 people found this helpful
After a few weeks of using this product, my chronic fatigue syndrome has improved significantly. The strawberry flavour is appealing, and the quick-dissolving tablets make it convenient. I’ve noticed increased energy levels and better mental clarity.
9
Increases energy
Vitamin B12 has been invaluable in tackling my chronic fatigue syndrome. After a few weeks, I felt more energetic and clear-minded.
7.5
Muscle recovery
1 people found this helpful
Since I started taking this for chronic fatigue syndrome, I’ve noticed my muscles recover better. One tablet each morning ensures I feel better throughout the day compared to when I don’t take it.
7.5
Nervous system support
1 people found this helpful
I find that Vitamin B12 supports my nervous system and combats irritability related to chronic fatigue syndrome, providing me with all-day energy and better sleep.
7.5
Improved mental state
The ingredients are adequate for improving problems associated with chronic fatigue syndrome. B12 is beneficial for the body, and I haven't experienced any adverse reactions after consumption. My mental state is noticeably better, and the quality is good.
6
Decreased fatigue
A megadose of four tablets daily slightly reduced my fatigue related to chronic fatigue syndrome.
8
Vitamin B12 benefits in CFS patients
Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
8
B12 shows variable efficacy for ME
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
References
van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. 10.3389/fphar.2019.01102
Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594.
Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301.
Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.